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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

Gebonden Engels 2012 2012e druk 9789400743144
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.

Specificaties

ISBN13:9789400743144
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:406
Uitgever:Springer Netherlands
Druk:2012

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Inhoudsopgave

<p>1. History and prospects of Coxiella burnetii research; Karim E. Hechemy</p><p>2. Phylogenetic diversity, virulence and comparative genomics; Erin J. van Schaik and James E. Samuel</p><p>3. Defense mechanisms against oxidative stress in Coxiella burnetii: Adaptation to a unique intracellular niche; Katja Mertens and James E. Samuel</p><p>4. Lipopolysaccharide of Coxiella burnetii; Craig T. Narasaki and Rudolf Toman</p><p>5. Components of protective immunity; Guoquan Zhang, Yan Zhang and James Samuel<p>6. Proteome of Coxiella burnetii; Robert Ihnatko, Edward Shaw and Rudolf Toman</p><p>7. Coxiella subversion of intracellular host signaling; S. Kauser Hussain and Daniel E. Voth</p><p>8. The Coxiella burnetii parasitophorous vacuole; Eric Ghigo, María I. Colombo and Robert A. Heinzen</p><p>9. Coxiella burnetii secretion systems; Justin A. McDonough, Hayley J. Newton and Craig R. Roy</p><p>10. Role of lipids in Coxiella burnetii infection; Stacey D. Gilk</p><p>11. Axenic growth of Coxiella burnetii; Anders Omsland</p><p>12. Developmental biology of Coxiella burnetii; Michael F. Minnick and Rahul Raghavan </p><p>13. Genetic manipulation of Coxiella burnetii; Paul A. Beare</p><p>14. Role of innate and adaptive immunity in the control of Q fever; Christian Capo and Jean-Louis Mege</p><p>15. Immune response and Coxiella burnetii invasion; Amira Ben Amara, Yassina Bechah and Jean-Louis Mege</p><p>16. Antigenic analysis for vaccines and diagnostics; Laura R. Hendrix and Chen Chen</p><p>17. Epidemic Q Fever in humans in the Netherlands; Wim van der Hoek, Gabriëlla Morroy, Nicole H.M. Renders, Peter C. Wever, Mirjam H.A. Hermans, Alexander C.A.P. Leenders, and Peter M. Schneeberger</p><p>18. Coxiella-like endosymbionts; Jianmin Zhong</p><p>19. Molecular typing of Coxiella burnetii (Q fever); Robert Massung, Sally Cutler and Dimitrios Frangoulidis</p></p><p>

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        Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium