Microdomains in the Cardiovascular System

Receptor-cyclic nucleotide microdomains in the heart.- Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes.-Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase Anchoring Proteins.-  Pharmacological approaches for delineating functions of AKAP-base signalling complexes and finding therapeutic targets.- Chatting second messengers: PIP3 and cAMP.-Cyclic nucleotide phosphodiesterases and compartmentation in normal and diseased heart.-cAMP compartmentalisation and hypertrophy of the heart: ‘good’ pools of cAMP and ‘bad’ pools of cAMP coexist in the same cardiac myocyte.-  Subcellular targeting of PDE4 in cardiac myocytes and generation of signaling compartments.-  Cardiac cAMP microdomains and their modulation using disruptor peptides.-  Computational modelling of cyclic nucleotide signaling mechanisms in cardiac myocytes.- SIGNALING MICRODOMAINS: THE  BETA3 ADRENERGIC RECEPTOR/NOS SIGNALOSOME.- Compartmentation of natriuretic peptide signalling in cardiac myocytes – effects on cardiac contractility and hypertrophy.- Cyclic GMP/Protein Kinase Localized Signaling and Disease Implications.- Distribution and regulation of L-type Ca²⁺ channels in cardiomyocyte microdomains.- The Role of Local Ca²⁺ Release for Ca²⁺ Alternans and SR Ca²⁺ Leak .- The control of sub-plasma membrane calcium signalling by the plasma membrane calcium ATPase pump PMCA4.- Calcium microdomains in cardiac cells.<p></p><p></p><p></p><p> <br/></p><p> <br/></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p> <p></p><p></p><p></p>