Chemistry of Metalloproteins – Problems and Solutions in Bioinorganic Chemistry
Problems and Solutions in Bioinorganic Chemistry
Paperback Engels 2014 9781118470442Samenvatting
Addresses the full gamut of questions in metalloprotein science Formatted as a question–and–answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B 12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
Specificaties
Lezersrecensies
Inhoudsopgave
<p>1 Introduction 1</p>
<p>Proteins: Formation, Structures, and Metalloproteins, 4</p>
<p>References, 28</p>
<p>2 Alkali and Alkaline Earth Cations 31</p>
<p>References, 67</p>
<p>3 Nonredox Metalloenzymes 71</p>
<p>Carboxypeptidases, 75</p>
<p>Carbonic Anhydrase, 84</p>
<p>Alcohol Dehydrogenase, 88</p>
<p>References, 91</p>
<p>4 Copper Proteins 95</p>
<p>Introduction, 95</p>
<p>Electronic Spectra of Copper Ions, 96</p>
<p>ESR Spectra of Copper Ions, 105</p>
<p>Copper Proteins, 117</p>
<p>Plastocyanin, 119</p>
<p>Azurin and Stellacyanin, 127</p>
<p>Superoxide Dismutase, 131</p>
<p>Hemocyanin, 135</p>
<p>Ascorbic Oxidase, 139</p>
<p>References, 142</p>
<p>5 Iron Proteins 147</p>
<p>Introduction, 147</p>
<p>Electronic Spectra of Iron Ions, 148</p>
<p>Mössbauer Spectroscopy of Iron Ions, 155</p>
<p>ESR Spectra of Iron (III), 161</p>
<p>Iron Bioavailability, 166</p>
<p>Siderophores, 171</p>
<p>Iron Storage and Transfer Proteins, 184</p>
<p>Ferritin, 184</p>
<p>Transferrin, 187</p>
<p>Dioxygenase Iron Proteins, 195</p>
<p>Iron Sulfur Proteins, 207</p>
<p>Rubredoxin, 207</p>
<p>Ferredoxins, 212</p>
<p>2Fe 2S Ferredoxins, 212</p>
<p>4Fe 4S Ferredoxins, 221</p>
<p>Aconitase, 226</p>
<p>Hydroxylases, 229</p>
<p>Hydrogenases, 232</p>
<p>Nitrogenases, 240</p>
<p>Binuclear Iron Proteins, 251</p>
<p>Hemerythrin, 253</p>
<p>Ribotide Reductase, Purple Acid Phosphate, and Methane Monooxygenase, 260</p>
<p>Hemoproteins: Classification and Behavior of Heme in Absence of Globins, 267</p>
<p>Myoglobin and Hemoglobin, 275</p>
<p>Myoglobin, 275</p>
<p>Hemoglobin, 280</p>
<p>Cytochrome C, 298</p>
<p>Electron Transfer in Porphyrins and Metalloporphyrins, 301</p>
<p>Catalases, 311</p>
<p>Peroxidases, 315</p>
<p>Cytochrome P–450, 322</p>
<p>Electronic Spectra of Hemoproteins, 327</p>
<p>ESR Spectra of Hemoproteins, 362</p>
<p>References, 378</p>
<p>6 Vitamin B12 393</p>
<p>References, 405</p>
<p>7 Chlorophyll 407</p>
<p>References, 421</p>
<p>Index 423</p>
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